Friday, June 28, 2013

Perry, filibuster star clash over Texas abortions

GRAPEVINE, Texas (AP) ? Gov. Rick Perry hit back Thursday at the star of a Democratic filibuster that helped kill new Texas abortion restrictions, saying state Sen. Wendy Davis' rise from a tough upbringing to Harvard Law graduate should have taught her the value of each human life.

The Republican governor expanded on those remarks later, publicly wondering what might have happened if Davis' own mother had undergone an abortion rather than carry her child to term.

Davis, a Fort Worth Democrat, shot back that Perry's statement "tarnishes the high office he holds."

Before the white-hot battle over abortion in the nation's second-largest state turned personal, Davis staged a marathon filibuster Tuesday helping to defeat an omnibus bill that would have further limited abortions in a place where it's already difficult to undergo them. But Perry called lawmakers back for a second special session next week to try and finish the job.

"Who are we to say that children born in the worst of circumstances can't lead successful lives?" Perry said in a speech to nearly 1,000 delegates at the National Right to Life Conference in suburban Dallas. "Even the woman who filibustered the Senate the other day was born into difficult circumstances."

Davis, 50, has rocketed to sudden, national political stardom thanks to donning pink tennis shoes and delivering the marathon speech on the floor of the state Senate.

She started working at age 14 to help support a household of her single mother and three siblings. By 19, she was already married and divorced with a child of her own, but she eventually graduated with honors from Harvard Law School and won her Senate seat in an upset.

Perry pointed out that personal history in his speech, adding "it's just unfortunate that she hasn't learned from her own example that every life must be given a chance to realize its full potential and that every life matters."

In comments to reporters afterward, he went even further.

"I'm proud that she's been able to take advantage of her intellect and her hard work, but she didn't come from particularly good circumstances," the governor said. "What if her mom had said, 'I just can't do this. I don't want to do this.' At that particular point in time I think it becomes very personal."

Davis quickly fired off an email blasting Perry's comments.

"They are small words that reflect a dark and negative point of view," she said. "Our governor should reflect our Texas values. Sadly, Gov. Perry fails that test."

Davis' supporters argued Perry never would have made such suggestions to a male politician.

"Rick Perry's remarks are incredibly condescending and insulting to women," Cecile Richards, president of Planned Parenthood Action Fund and daughter of the late former Texas Gov. Ann Richards, said in a statement. "This is exactly why the vast majority of Texans believe that politicians shouldn't be involved in a woman's personal health care decisions."

The Texas Legislature adjourned May 27, but Perry called legislators into a first 30-day special session to pass stricter limits on abortion, including banning the procedure after 20 weeks of pregnancy. But with the extra session set to end at midnight on Tuesday, Davis was on her feet for more than 12 hours ? speaking most of that time ? as Senate Democrats attempted a filibuster.

Just before the final gavel, Republican lawmakers silenced her for addressing a topic other than the bill she was opposing ? only to have hundreds of abortion rights activists cheer so loudly from the public gallery that all business in the chamber halted until it was too late.

Perry, a conservative and devout Christian, has put the abortion measure at the top of the agenda for the second special session, which begins Monday. It would force many clinics that perform abortions to upgrade their facilities to be classified as ambulatory surgical centers. Doctors also would be required to have admitting privileges at a hospital within 30 miles.

Opponents say such improvements are so expensive that only five of Texas' 42 abortion clinics would remain in operation.

Abortion rights groups have promised to respond with more protests, including one scheduled Monday for the state Capitol. Perry, meanwhile, called those who oppose abortion to action, telling the conference, "the world has seen images of pro-abortion activists screaming, cheering. Going forward, we have to match their intensity."

Adding intrigue to his grudge match with Davis is the fact that Perry had been expected to announce this week if he will seek a fourth full term as governor next year. But he said Thursday that announcement will now be delayed until lawmakers can finish the extra work he's given them.

Davis is up for re-election too next year, but had been urged by Democratic operatives even before her filibuster to consider running for governor.

She has acknowledged mulling a run for statewide office but says she wants to wait for the right time. A Democrat hasn't won such a post in Texas since 1994, and the state Democratic Party would face a major challenge establishing the organization or infrastructure necessary to deliver enough dependable votes.

Asked what he thought of Davis as a possible gubernatorial candidate, Perry shrugged and said: "I don't have a clue."

Source: http://news.yahoo.com/perry-filibuster-star-clash-over-texas-abortions-175240836.html

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89% In the House

All Critics (70) | Top Critics (24) | Fresh (62) | Rotten (8)

The film treats imagination-and talent-in certain hands as an almost mystical force.

Ozon and the script move a little too far afield and hold on a bit too long as the film approaches its end. Still, "In the House" has enough trippy truth to it to grab your interest and shake your mind.

It's fiction about life that becomes fiction that might be life - and the viewer happily dives in.

The expected punch line... never materializes, so I guess this must be a drama after all.

Savor In the House for its meta-exploration of adolescence, class resentment and suppressed desire, but don't expect much more.

The seductions of storytelling drive "In the House," a cleverly structured comic thriller rich with narrative trickery and macabre humor.

Provocative, playful, entertaining and audacious, In the House is a writer showing us the inner workings of writing, complete with its power to subvert, to imagine and to deceive

Occasionally too clever for its own good, the film may go one step too far, but Ozon manages the hybrid of genres beautifully and ultimately it is his superb cast that sells the nuances and the concept

A sly, stylish blend of melodrama and suspense that's also a cunning commentary on the seductiveness and danger inherent in storytelling itself.

Director/scriptwriter Francois Ozon knows his Hitchcock well. He employs him effectively, but the clutter is his own.

An almost perverse delight, an egghead thriller that slyly shell-games its truer purpose as an inquiry into the construction -- and deconstruction -- of fiction. Scratch deconstruction: Make that tear-the-house-down demolition.

It's partly real and partly a fable, full of events that might have happened or could never have happened, with intrigues that defy us to take them seriously.

In the House is a structurally solid thriller that is both inventive and absolutely seductive in nature.

Inviting photography and a relentless pace complement Claude's unfolding narrative, but the big thrills are in the deftly drawn characters...and the incisive satire...

A slick psychological thriller that veers into dark comedy the more absurd it gets, "In the House" demonstrates the dangers of addiction -- not to sex or drugs, but to story.

Captures why we do what we do, and the extent to which stories reflect both the writer and the reader.

It's amusing and unexpected, capturing the compulsive spirit of writing with wit and attention to mischief that keeps it unpredictable to the very end.

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Source: http://www.rottentomatoes.com/m/in_the_house_2013/

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Wednesday, June 26, 2013

Kemp returns, saves Dodgers in 6-5 win over Giants

Los Angeles Dodgers center fielder Matt Kemp makes a catch on a ball hit by San Francisco Giants' Marco Scutaro to end their baseball game, Tuesday, June 25, 2013, in Los Angeles. The Dodgers beat the Giants 6-5. (AP Photo/Mark J. Terrill)

Los Angeles Dodgers center fielder Matt Kemp makes a catch on a ball hit by San Francisco Giants' Marco Scutaro to end their baseball game, Tuesday, June 25, 2013, in Los Angeles. The Dodgers beat the Giants 6-5. (AP Photo/Mark J. Terrill)

Los Angeles Dodgers center fielder Matt Kemp, right, celebrates with right fielder Andre Ethierafter making a catch on a ball hit by San Francisco Giants' Marco Scutaro to end their baseball game, Tuesday, June 25, 2013, in Los Angeles. The Dodgers beat the Giants 6-5. (AP Photo/Mark J. Terrill)

Los Angeles Dodgers center fielder Matt Kemp, center, celebrates with right fielder Yasiel Puig, left, as right fielder Andre Ethier looks on after making a catch on a ball hit by San Francisco Giants' Marco Scutaro to end their baseball game, Tuesday, June 25, 2013, in Los Angeles. The Dodgers beat the Giants 6-5. (AP Photo/Mark J. Terrill)

Los Angeles Dodgers' Matt Kemp reacts after scoring on a single by Tim Federowicz during the sixth inning of their baseball game against the San Francisco Giants, Tuesday, June 25, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Los Angeles Dodgers' Hanley Ramirez, right, hits a two-run home run as San Francisco Giants catcher Buster Posey, lower left, and home plate umpire D.J. Rayburn look during the sixth inning of their baseball game, Tuesday, June 25, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

(AP) ? Matt Kemp was insistent about getting back into the Los Angeles Dodgers' lineup Tuesday night after three frustrating weeks on the disabled list, and the last thing on his mind was whether his troublesome right hamstring would hold up.

So when it came time to test his leg, it passed with flying colors.

Kemp ran a long way and made a marvelous catch for the final out of a 6-5 victory over the slumping San Francisco Giants, extending Los Angeles' winning streak to a season-best four games.

"You can't really think like that," Kemp said when asked if he was relieved he didn't hurt his hamstring again. "I mean, I've thought like that after I came back from it last year, and it happened again. So I can't play timid. I have to let it go. And if it goes, it goes. Hamstrings are tricky, and you never know when they're good. But right now it feels good and I'm glad we got the win."

With runners at first and second, Marco Scutaro hit a long drive to center. Kemp, playing shallow with the potential tying run at second base, raced back and reached over his shoulder to make a sliding catch on the warning track. He popped up and smacked the wall hard, then shouted in excitement.

"Scutaro doesn't really drive the ball to center field like that, so he surprised me a little bit," the two-time Gold Glove winner said. "He's a good contact hitter that likes to drive the ball the other way in the hole and back up the middle, so I was just anticipating him trying to hit a ground ball up the middle, and he hit it pretty good. So I had to drop my head and run back."

Scutaro is homerless in 142 career at-bats against the Dodgers.

"I thought it had a good shot to go out," Giants shortstop Brandon Crawford said. "It looked like he hit it well, but I knew Kemp was out there and he's a good center fielder. So he was going to do all he could to not let it drop. It was bad luck for us. That's kind of what's been happening a lot to us lately."

Kemp returned to the lineup after missing 24 games with a right hamstring strain. He was injured May 29 while running down a double in right-center by Mike Trout at Angel Stadium. It was the fourth time in his career that Kemp landed on the DL, including two stints last season because of a left hamstring strain that cost him a combined 51 games.

"I had to beg him to let me play today," Kemp said, referring to manager Don Mattingly. "I was telling him I was just sick of watching my team play without me. It kind of feels like you're not part of the team when you're on the DL, so I just wanted to get back out there with the guys."

Mark Ellis and Hanley Ramirez each hit a two-run homer for the Dodgers, and rookie Stephen Fife pitched effectively into the seventh inning. Los Angeles handed the defending World Series champions their third loss in a row and eighth in 11 games, dropping them under .500 for the first time since losing to the Dodgers on opening day.

It's the latest the Giants have been below the break-even mark in any season since 2008, when they finished 72-90 in Bruce Bochy's second year as manager.

"Honestly, I didn't even know we were under .500. I just knew we haven't been playing well. That's a wake-up call in itself," Crawford said.

Fife (2-2) allowed three runs and four hits, including solo homers by Brandon Belt and NL MVP Buster Posey, in 6 2-3 innings. The 26-year-old right-hander struck out three and walked two in his 11th major league start, only the second in which he gave up more than two runs.

With closer Kenley Jansen unavailable after pitching three consecutive days, demoted closer Brandon League came on in the ninth to protect a 6-3 lead and did not retire any of the three batters he faced.

Belt hit an RBI double and Andres Torres added an RBI single off League before Paco Gonzalez got three outs for his first major league save ? barely.

Mike Kickham (0-2) was charged with six runs, five earned, and eight hits over 5 1-3 innings in his second big league start.

The Dodgers broke a 2-all tie with four runs in the sixth. Adrian Gonzalez doubled and Ramirez followed with a drive off the left-field foul pole for his fifth homer. Kickham gave up singles to his next two batters before rookie Jake Dunning came in and gave up an RBI single by Tim Federowicz.

Nick Punto kept the inning alive when he beat the relay throw to first base with a headfirst slide on a potential double-play grounder. Andre Ethier then scored on Dunning's wild pitch to Fife.

Belt, who was 3 for 4 after coming in 4 for 43 lifetime at Dodger Stadium, got one of the runs back for the Giants in the seventh with his eighth homer.

Fife retired his first 11 batters before Posey drove an 0-1 pitch barely over the left-field fence for his ninth homer. The Giants tied it in the fifth on a run-scoring groundout by Torres.

Ellis opened the scoring with his fourth homer, a two-run shot with two outs in the third after Federowicz led off with a double.

NOTES: Punto, starting at 3B while Juan Uribe got the night off, jumped to pull down Pablo Sandoval's line drive in the second inning. Hunter Pence, the next batter, lifted a popup toward the stands and Punto stretched over the barrier before landing in the first row with the ball in his glove. ... Kemp was 1 for 4 with a single. He is homerless in 106 at-bats at Dodger Stadium since his two-run shot off Colorado's Jorge De La Rosa last Sept. 20. ... The Giants have been outhomered 19-5 over their last 15 games. ... The Dodgers, who were 11-13 in Kemp's absence, opened a roster spot for him by optioning INF-OF Elian Herrera to Triple-A Albuquerque. ... Giants CF Angel Pagan had surgery in Los Angeles to repair a tendon in his left hamstring, an injury that has sidelined him since May 26.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-26-BBN-Giants-Dodgers/id-5f49d7249d9b4ed6b4e2143967281b7e

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The New X-M1 Is Fujifilm's Cheapest Mirrorless Camera Yet

The New X-M1 Is Fujifilm's Cheapest Mirrorless Camera Yet

The rumored "entry-level" X-series interchangeable-lens camera from Fujifilm is real. The X-M1, features the same 16.3-megapixel APS-C sensor from the more-expensive X-Pro1 and X-E1 models.

Read more...

    


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Tuesday, June 25, 2013

Putin: 'Nyet' to US request to turn over Snowden

Russian President Vladimir Putin speaks to the media following a meeting with the Finland's President Sauli Niinisto at the presidential summer residence Kultaranta in Naantali, Finland, Tuesday June 25, 2013. (AP Photo/Lehtikuva, Kimmo Mantyla) FINLAND OUT

Russian President Vladimir Putin speaks to the media following a meeting with the Finland's President Sauli Niinisto at the presidential summer residence Kultaranta in Naantali, Finland, Tuesday June 25, 2013. (AP Photo/Lehtikuva, Kimmo Mantyla) FINLAND OUT

FILE - In this June 21, 2013 file photo, a banner supporting Edward Snowden, a former CIA employee who leaked top-secret documents about sweeping U.S. surveillance programs, is displayed at Central, Hong Kong's business district. The Hong Kong government says Snowden wanted by the U.S. for revealing two highly classified surveillance programs has left for a "third country." The South China Morning Post reported Sunday, June 23, 2013 that Snowden was on a plane for Moscow, but that Russia was not his final destination. Snowden has talked of seeking asylum in Iceland. (AP Photo/Kin Cheung, File)

Russia's Foreign Minister Sergey Lavrov speaks at a news conference in Moscow on Tuesday, June 25, 2013. Lavrov on Tuesday bluntly rejected U.S. demands to extradite National Security Agency leaker Edward Snowden, saying that Snowden hasn?t crossed the Russian border as he seeks to evade prosecution. Sergey Lavrov insisted that Russia has nothing to do with Snowden or his travel plans. Lavrov wouldn?t say where Snowden is, but he angrily lashed out at the U.S. for demanding his extradition and warnings of negative consequences if Moscow fails to comply. (AP Photo/Ivan Sekretarev)

Russia's Foreign Minister Sergey Lavrov speaks at a news conference in Moscow on Tuesday, June 25, 2013. Lavrov on Tuesday bluntly rejected U.S. demands to extradite National Security Agency leaker Edward Snowden, saying that Snowden hasn?t crossed the Russian border as he seeks to evade prosecution. Sergey Lavrov insisted that Russia has nothing to do with Snowden or his travel plans. Lavrov wouldn?t say where Snowden is, but he angrily lashed out at the U.S. for demanding his extradition and warnings of negative consequences if Moscow fails to comply. (AP Photo/Ivan Sekretarev)

Ecuador's President Rafael Correa, right, greets passersby from the balcony of the presidential palace during the weekly, The Change of the Guard, in Quito, Ecuador, Monday, June 24, 2013. The Ecuadorian government declared Monday that national sovereignty and universal principles of human rights would govern their decision on granting asylum to Edward Snowden, powerful hints that the former National Security Agency contractor is welcome despite potential repercussions from Washington. Correa said on Twitter that "we will take the decision that we feel most suitable, with absolute sovereignty." AP Photo/Dolores Ochoa)

(AP) ? Yes, he's at a Moscow airport, and no, you can't have him.

Russian President Vladimir Putin gave the first official acknowledgment of the whereabouts of National Security Agency leaker Edward Snowden on Tuesday and promptly rejected U.S. pleas to turn him over.

Snowden, who is charged with violating American espionage laws, fled Hong Kong over the weekend, touching off a global guessing game over where he went and frustrating U.S. efforts to bring him to justice.

Putin said Snowden is in the transit zone of Sheremetyevo Airport and has not passed through Russian immigration, meaning he technically is not in Russia and thus is free to travel wherever he wants.

After arriving Sunday on a flight from Hong Kong, Snowden registered for a Havana-bound flight Monday en route to Venezuela and then possible asylum in Ecuador, but he didn't board the plane.

Speculation has been rife that Russian security services have been talking to Snowden and might want to keep him in Russia for a more thorough debriefing, but Putin denied that.

"Our special services never worked with Mr. Snowden and aren't working with him today," Putin said at a news conference during a visit to Finland.

Because Moscow has no extradition agreement with Washington, it cannot meet the U.S. request, he said.

"Mr. Snowden is a free man, and the sooner he chooses his final destination the better it is for us and for him," Putin said. "I hope it will not affect the businesslike character of our relations with the U.S. and I hope that our partners will understand that."

U.S. Secretary of State John Kerry said Tuesday that the U.S. wants Russia to show respect for the rule of law and comply with common practices when it comes to fugitives from justice.

Putin's staunch refusal to consider deportation shows his readiness to further challenge Washington at a time when U.S.-Russian relations are already strained over Syria and other issues, including a Russian ban on adoptions by Americans.

"Just showing America that we don't care about our relations, we are down to basically a Cold War pattern: The enemy of your government is our friend," said Masha Lipman of the Carnegie Moscow Center.

"The Russian administration has not come that far, but we don't know what it's up to," she said.

Despite Putin's denial, security experts believe Russia's special services wouldn't miss the chance to question a man who is believed to hold reams of classified U.S. documents and could shed light on how the U.S. intelligence agencies collect information.

Igor Korotchenko, director of the Center for Global Arms Trade and editor of National Defense Magazine, said Snowden would be of particular interest because little is known about digital espionage.

"The security services would be happy to enter into contact with Mr. Snowden," Korotchenko said.

Russia also has relished using Snowden's revelations to turn the tables on the U.S. over its criticism of Russia's rights record.

Putin compared Snowden to WikiLeaks founder Julian Assange, who has been given asylum in the Ecuadorean Embassy in London, saying that both men were labeled criminals but consider themselves rights activists and champions of freedom of information.

"Ask yourself a question: Should people like that be extradited so that they put them in prison?" he said. "In any case, I would prefer not to deal with such issues. It's like shearing a piglet: a lot of squealing and little wool."

In an apparent reference to claims that Russia could have played a role in Snowden's exit from Hong Kong, Putin said his arrival in Moscow was a "complete surprise" and dismissed such accusations as "ravings and sheer nonsense."

"He doesn't need a visa or any other documents, and as a transit passenger he has the right to buy a ticket and fly wherever he wants," Putin said.

Snowden, 30, is a former CIA employee who later was hired as a contractor for the NSA. In that job, he gained access to documents that he gave to newspapers the Guardian and The Washington Post to expose what he contends are privacy violations by an authoritarian government.

Snowden also told the South China Morning Post newspaper in Hong Kong that "the NSA does all kinds of things like hack Chinese cellphone companies to steal all of your SMS data." He is believed to have more than 200 additional sensitive documents in laptops he is carrying.

Russian news media had reported that Snowden remained in a transit zone at the airport, which is separate from regular departure areas. He has not been seen by any of the journalists who have been roaming Sheremetyevo in search of him, furthering speculation that he had been secreted away.

The Interfax news agency, citing an unidentified airport official, said Snowden could be staying in a room in the transit zone normally reserved for flight crews and other personnel.

Legally, an arriving air passenger only crosses the border after clearing Russian immigration checks.

Earlier Tuesday, Foreign Minister Sergey Lavrov rejected the U.S. push to turn over Snowden, but he wouldn't specify his whereabouts, saying only that he hadn't crossed the Russian border.

Kerry called for "calm and reasonableness."

"We would hope that Russia would not side with someone who is a fugitive from justice," Kerry said at a news conference in Saudi Arabia.

The U.S. has revoked Snowden's passport.

A representative of WikiLeaks has been traveling with Snowden, and the secret-spilling organization is believed to be assisting him in arranging asylum. Assange, the group's founder, said Monday that Snowden was only passing through Russia and had applied for asylum in Ecuador, Iceland and possibly other countries.

A high-ranking Ecuadorean official told The Associated Press that Russia and Ecuador were discussing where Snowden could go, saying the process could take days. He also said Ecuador's ambassador to Moscow had not seen or spoken to Snowden. The official spoke on condition of anonymity because he was not authorized to discuss the case publicly.

The Kremlin has previously said Russia would be ready to consider Snowden's request for asylum.

Some observers said Snowden's revelations have provided the Kremlin with propaganda arguments to counter the U.S. criticism of Russia's crackdown on opposition and civil activists under Putin.

"They would use Snowden to demonstrate that the U.S. government doesn't sympathize with the ideals of freedom of information, conceals key information from the public and stands ready to open criminal proceedings against those who oppose it," Konstantin Remchukov, the editor of independent daily Nezavisimaya Gazeta, said on Ekho Moskvy radio.

Putin has accused the U.S. State Department of instigating protests in Moscow against his re-election for a third term in March and has taken an anti-American posture that plays well with his core support base of industrial workers and state employees.

____

Huuhtanen reported from Naantali, Finland. Associated Press writers Lynn Berry in Moscow and Michael Weissenstein and Gonzalo Solano in Quito, Ecuador, contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-06-25-NSA-Surveillance/id-fd778922546b4e9986b068badefa9986

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Monday, June 17, 2013

Page Not Found - Yahoo!

Please check the URL for proper spelling and capitalization. If you're having trouble locating a destination on Yahoo!, try visiting the Yahoo! homepage or look through a list of Yahoo!'s online services.

Please try Yahoo Help Central if you need more assistance.

Source: http://rss.news.yahoo.com/rss/techblog

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In Florida, Nik Wallenda readies for Grand Canyon high-wire act

By Saundra Amrhein

SARASOTA, Florida (Reuters) - Dressed casually in a T-shirt, calf-length cargo pants and flip-flops, Nik Wallenda looks no different from many of the hundreds of spectators who have turned out in recent days to watch him practice for his next high-wire act.

There are no pretentious airs about him, and no spangled outfits.

"Hey, how ya doing, man?" he asked while stopping to shake the hand of a man trying to take his picture with an iPad and then pausing to high-five a few kids.

But what Wallenda is preparing for is anything but routine.

For two weeks in his hometown of Sarasota, Florida, the aerialist and holder of half a dozen world records has been practicing for what will be his biggest feat yet - a quarter-mile (400-metre) walk across the Grand Canyon on a steel cable with nothing but the Little Colorado River 1,500 feet below.

With no tethers or safety nets, the walk will be the highest tightrope attempt ever for the 34-year-old, at a height taller than the Empire State Building. It is scheduled to be shown live on June 23 on the Discovery Channel.

Last year, Wallenda, a seventh-generation member of the "Flying Wallendas" family of acrobats, became the only person to walk a wire over the brink of Niagara Falls.

Wallenda and his team are focused on creating the conditions he'll likely face at the Grand Canyon. The Florida heat, while humid as opposed to arid, cooperates, with temperatures rising through the 80s (27-32 C) by mid-morning.

But the winds that whip up and around the Grand Canyon walls pose another challenge. Wallenda recently faced heavy winds during a test run and practiced as Tropical Storm Andrea barreled onshore along the Gulf Coast.

To ramp up conditions without a storm, his team one day set up air boats in the water alongside the steel cable he uses to practice on, pushing winds in updrafts to 91 mph.

The canyon's winds won't bother him, he said.

"I'm not scared of them," he said while gliding along the cable, his flip-flops replaced by black moccasins specially made by his mother.

REAL DANGERS

As he walked and spoke, spectators watched from behind metal parade barricades. "I have to respect it, but I would never do what I do if I was scared," he said.

Wallenda regularly emphasizes mental concentration and positive thinking as the secrets to his success.

Since he started walking on a wire at age 2, he has been stung by a bee and had birds land on his balancing pole during performances.

He told reporters that he has no superstitions or rituals before his walks. He prays - his Christian faith plays a big part in his new book "Balance" - and hugs his wife and three children, telling them he'll see them in a few minutes.

With spectators' eyed glued on him, Wallenda and his balancing pole made one trip along the 1,200-foot (366-metre) cable and back, projecting the image of a body builder and a ballet dancer combined. Then he sat down - on the cable.

"Does anyone have any questions?" he asked the crowd, his legs dangling from his perch.

They did. How heavy is the balancing pole? Forty-three pounds (20 kg). Does he work out? Yes, at the gym. How long will it take him to cross the Grand Canyon? Twenty to thirty minutes.

Wallenda spoke openly about the reality of the dangers - including the ones that claimed his great-grandfather, Karl Wallenda, a great inspiration to him.

In 1978, the legendary sky walker fell to his death during a high-wire walk in Puerto Rico, a tragedy that Wallenda said studies showed was caused by a combination of bad rigging and his great-grandfather's age and recent injuries that left him too weak to hold on to the wire.

"There's a time to retire," he said.

But Wallenda is not there yet, as he readies to embark on what has been a dream for years.

It's a dream with a 1,500-foot drop below him, which will be "extremely mentally draining," he said.

(Editing by Kevin Gray and Eric Walsh)

Source: http://news.yahoo.com/florida-nik-wallenda-readies-grand-canyon-high-wire-201220347.html

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Submissions for Expand's Insert Coin: New Challengers competition now open!

Calling all makers, dreamers, inventors and entrepreneurs, Insert Coin: New Challengers is back for round two! We were absolutely blown away by the responses to our Expand San Francisco competition. We had a hell of a time whittling all of the submissions down to a group of semi-finalists and had a blast interacting with all of the finalists on the show floor. Ultimately, Ziphius' head-turning aquatic drone took home the gold, a well-deserved and hard fought win. This time out, we'll giving 10 semifinalists tickets to the show, along with a $1,000 travel stipend. One Judges' Choice winner will walk away with $10,000 and one Readers' Choice winner will get $15,000. Both will also score a product review on this site.

Think you've got what it takes to walk away with the big prize at Expand NY in November? Well, now's your chance. We're opening up submissions today through September 27th. Semifinalists will be announced on this site and the big winners will be unveiled at the show. Submissions rules can be found after the break and over on our event page. We can't wait to see what you've got cooking this time out!

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Sunday, June 16, 2013

Dawn Approach new favourite for St James's Palace Stakes ... - Bettor

Dawn Approach new favourite for St James?s Palace Stakes ? Horseracing news

Dawn Approach has been named as the new favourite for the St James?s Palace Stakes following his impressive workout recently.

He was not expected to be back in action this early after his lacklustre showing in the Investec Derby, but things have been moving on in the right direction for him.

Moreover, it is expected that Magician will miss out on the major event, which means that there will be no real challenge for the 2,000 Guineas winner.

According to the favourite trainer Jim Bolger, ?Dawn Approach worked this morning and all went well. I was happy with him and he will be travelling to Ascot.?

The three-year-old colt was priced as the favourite to win the Investec Derby, but a small incident at the start of the race cost him a chance to maintain his 100 percent winning record. He had a little collision with another horse, which simply put him out of control of the rider Kevin Manning.

As a result, Bolger?s trainee finished right at the bottom of the table, which was quite shocking for the entire camp and the horseracing fans.

Right after that race, it was revealed that the quality stallion will be rested for some time, thus might end up missing the Royal Ascot. However, he showed impressive form in all of the practice sessions and encouraged his camp to run him in the St James's Palace Stakes.

This was positive news for Manning, who said of his challenger, ?I'm happy with him, he's very relaxed and feels the same as he did before the 2,000 Guineas. I thought Magician was very impressive at both Chester and in the Irish 2,000 Guineas and he looks very smart. This is what it's about, the best taking each other on.?

Dawn Approach has participated in a total of eight races in his career, winning seven of them. He will not be able to emulate what Frankel did, but that does not make him a less good stallion. He has got a couple of more years to dominate his rivals and if he manages to do that, his lone loss will be forgotten by everyone.

Source: http://blogs.bettor.com/Dawn-Approach-new-favourite-for-St-Jamess-Palace-Stakes-Horseracing-news-a216653

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Doddridge News: VA Home Loans Can Help Servicemembers and ...

Doddridge News: VA Home Loans Can Help Servicemembers and Veterans Purchase, Refinance, or Adapt a Home

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VA Home Loans Can Help Servicemembers and Veterans Purchase, Refinance, or Adapt a Home

The Department of Veterans Affairs (VA) offers a variety of?home loan programs?for active duty?service members, veterans, and National Guard and Reserve members:?
  • Purchase Loans?help purchase a home at a competitive interest rate often without requiring a down payment or private mortgage insurance.
  • Cash Out Refinance Loans?take cash out of your home equity to pay off debt, fund school, or make home improvements.
  • Interest Rate Reduction Refinance Loan?can help you obtain a lower interest rate by refinancing an existing VA loan.
  • Native American Direct Loans?help eligible Native American veterans finance the purchase, construction, or improvement of homes on Federal Trust Land, or reduce the interest rate on a VA loan.
  • Adapted Housing Grants?help veterans with a permanent and total service-connected disability purchase or build an adapted home or to modify an existing home to account for their disability.

Source: http://www.doddridgenews.com/2013/06/va-home-loans-can-help-servicemembers.html

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Thursday, June 6, 2013

Rubio rounding up support for immigration bill

FILE - In this Oct. 5, 2011 file photo, Sen. Marco Rubio, R-Fla. speaks in Washington. Rubio is address House conservatives Wednesday afternoon June 5, 2013 on a far-reaching immigration bill. (AP Photo/Haraz N. Ghanbari, File)

FILE - In this Oct. 5, 2011 file photo, Sen. Marco Rubio, R-Fla. speaks in Washington. Rubio is address House conservatives Wednesday afternoon June 5, 2013 on a far-reaching immigration bill. (AP Photo/Haraz N. Ghanbari, File)

(AP) ? Senate debate on a far-reaching immigration bill is becoming a test of Sen. Marco Rubio's influence over fellow Republicans as the Florida conservative works to sell GOP lawmakers on landmark legislation that also may help determine the fate of his presidential ambitions.

Rubio, a tea party favorite who's acted as the bill's emissary to the conservative community, has spent recent weeks meeting individually with Republican senators to discuss changes to the bill that could get them on board. That included working with conservative Sen. John Cornyn, R-Texas, on a border security amendment Cornyn outlined Wednesday in The Dallas Morning News.

Rubio was to address House conservatives Wednesday, and he's been promoting the legislation with numerous TV and radio appearances. On Tuesday alone, he showed up on Fox News Channel, CNBC and Hugh Hewitt's talk radio show.

At the same time he's been making immigration advocates uneasy by issuing demands for stronger border security provisions in the legislation, including giving Congress more authority to write a border security plan instead of the Homeland Security Department. Rubio says he won't support the bill without such changes, and it won't be able to pass.

For Rubio, it's part of the balancing act he's been performing all year since joining more seasoned legislators like Sens. John McCain, R-Ariz., and Chuck Schumer, D-N.Y., as part of the so-called Gang of Eight senators who authored the immigration bill. His challenge is to maintain the support of the tea party backers who lend him credibility and leverage in the immigration debate, while also getting credit for pushing a landmark piece of legislation that's opposed by many in the tea party but is a priority to the Latino voters who increasingly help determine the outcome of presidential elections.

"He speaks their language, he's been one of them this entire time, he was a tea party favorite from the beginning," said Rebecca Tallent, director of immigration policy at the Bipartisan Policy Center, and a former aide to McCain. "Will he take some responsibility if they can't build a large coalition in the Senate? Absolutely. But so will the rest of the gang members."

The legislation, a priority for President Barack Obama, aims to boost border security and workplace enforcement, transform legal immigrant and worker programs and put some 11 million immigrants here illegally on a path to citizenship.

As the only author of the bill with the bona fides to sell it to conservatives, Rubio's been seen for months as key to its passage.

In recent weeks, Rubio's efforts have been largely behind the scenes as the Senate Judiciary Committee, of which Rubio is not a member, debated the legislation before approving it on a bipartisan vote. Now, with the full Senate set to take up the bill next week, Rubio's about to assume a more public role. His performance may spell success or failure for the bill and for his own political prospects as a potential presidential candidate in 2016.

Rubio and other backers of the bill are working to build support for the legislation in the Democratic-controlled Senate, convinced that a resounding vote that includes many Republicans would pressure the GOP-led House to act.

But for now, while support is all but assured from a large majority of the Senate's 54-member Democratic caucus (including two independents), only Rubio, McCain and the two other Republicans who helped write the bill ? Lindsey Graham of South Carolina and Jeff Flake of Arizona ? are definite "yes" votes among the GOP. On "Fox and Friends" on Tuesday, Rubio said the bill wouldn't have the 60 votes needed to pass the Senate without improvements.

Working with a list of 15 to 20 Republican senators who potentially could be persuaded to vote for the bill, Rubio's been meeting individually with lawmakers to hear their concerns. He worked with Cornyn on an amendment to enact tough new border requirements, including a biometric exit system at all airports and seaports, before any immigrant here illegally could achieve permanent legal residence. Sens. Tom Coburn, R-Okla., and Rob Portman, R-Ohio, said Tuesday they'd met with Rubio to discuss their concerns over border security and enforcement, and Portman said he was weighing amendments to address them.

Sen. Dean Heller, R-Nev., wrote an opinion piece in the Las Vegas Review-Journal last weekend in which he seemed open to the bill if improvements could be made and discussed meeting with Rubio to make them.

"He's done a great job selling this to conservative talk show hosts and others in the conservative community," McCain said.

But Rubio's moves unsettle liberals who fear that the insistence on establishing new border requirements first could end up making the path to citizenship unachievable.

"I just hope he doesn't think he can give away the store and count on the kind of unified Democratic support we have now," said Frank Sharry of America's Voice, an immigrant advocacy group.

One change Rubio has focused on would give Congress, instead of the Homeland Security Department, a bigger role in creating a border security plan since many Republicans are skeptical of the Obama administration's commitment to enforcing border security. As he described it on Hewitt's show Tuesday, the plan would be legislated as part of the immigration bill, although other Republicans, including Sen. Rand Paul, R-Ky., have discussed having Congress vote on whether the border has been secured.

"People don't want to just turn it over to the Homeland Security Department to come up with a plan," Rubio said. "They want the plan to be laid out specifically with real measurables, and I think that's a good approach and so we're working with members now to do that."

"If we can pass a measure that ensures that we will never again have another wave of illegal immigration, I believe we will have immigration reform. And if we do not pass that, if that does not happen, I believe there will not be immigration reform. It's as simple as that."

___

Follow Erica Werner on Twitter: https://twitter.com/ericawerner

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-05-Immigration/id-e45e95835ed14e019d03de88e6dabe00

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Thursday, May 16, 2013

Wal-Mart's 1Q profit, sales disappoint

In this May 9, 2013 photo, a worker pushes shopping carts in front of a Walmart store in La Habra, Calif. Wal-Mart Stores Inc. is expected to report quarterly results on Thursday, May 16, 2013. (AP Photo/Jae C. Hong)

In this May 9, 2013 photo, a worker pushes shopping carts in front of a Walmart store in La Habra, Calif. Wal-Mart Stores Inc. is expected to report quarterly results on Thursday, May 16, 2013. (AP Photo/Jae C. Hong)

NEW YORK (AP) ? The first few months of the year were tough for Wal-Mart Stores Inc.

The world's largest retailer reported Thursday that its first-quarter profit edged up just slightly, and the company struggled with a sales slump in its namesake business during the three-month period. The discounter also offered a quarterly profit outlook that came below Wall Street's projections. Its stock fell on the news.

Wal-Mart blamed a litany of factors affecting its budget-conscious customers, including a payroll tax increase, delayed tax refunds, job worries and bad weather. It is the latest in a string of big-name, consumer companies from McDonald's to Macy's, to cite such hurdles in the first quarter of the year.

"Frankly, we had a more difficult quarter than expected," said Wal-Mart's President and CEO Mike Duke in a pre-recorded call.

Wal-Mart is considered an economic bellwether because the retailer accounts for nearly 10 percent of nonautomotive retail spending in the U.S. The latest results indicate that many American households with lower incomes continue to struggle even as the job and housing markets improve.

"This is a reality check for Wal-Mart's low-income shoppers," said Brian Sozzi, CEO and chief equities strategist at Belus Capital Advisers. "The low-income shopper is even more financially stressed than people realize."

While the company said lingering cool weather into April was a culprit in a sales shortfall for seasonal goods like spring fashions and sporting goods such as camping gear, Charles Holley, Wal-Mart's chief financial officer, told reporters on a conference call that economic worries loom large.

"Our customers tell us that jobs and employment are high on the list of concerns," he said.

Additionally, like many companies, Wal-Mart said that business during the first quarter was hurt by the government's delay in processing income taxes and paying refunds. Wal-Mart said it cashed less in income tax refunds than a year ago.

Another big hurdle for Wal-Mart's financially strapped shoppers have been tax changes, which executives said started having more of an impact as the first quarter progressed. An increase in the payroll tax of two percentage points, which took effect Jan. 1, means that a take-home pay for a household earning $50,000 a year has been sliced by $1,000.

Such factors all helped to depress results. Wal-Mart earned $3.78 billion, or $1.14 per share, in the quarter that ended April 30. That compares with $3.74 billion, or $1.09 per share, a year earlier. Revenue rose 1 percent to $113.43 billion. That figure excludes Sam's Club membership fees. Results fell short of Wall Street expectations for earnings of $1.15 per share on revenue of $115.78 billion.

Revenue at stores open at least year, a key measurement for retailers because it excludes the effect of stores that open or close during the year, also fell below expectations.

Wal-Mart reported a 1.4 percent drop in revenue at stores open at least a year at its namesake business, which accounts for about 60 percent of the company's total revenue. That was the first drop since the second quarter of 2011. At Sam's Club, the figure rose just 0.2 percent, held down by less traffic from business customers, bad weather and lower-than-expected inflation.

Wall Street analysts had expected its U.S. namesake business to be unchanged and were projecting a 1.2 percent rise at Sam's Clubs.

Still, Wal-Mart said that business has picked up in May fueled in part because of warmer weather. The company expects revenue at stores opened at least a year to be up as much as 2 percent at its namesake U.S. business

Internationally, though, Wal-Mart faces slower growth amid a global recession.

A bribery scandal also threatens to slow its business overseas. Allegations first surfaced a year ago that Wal-Mart failed to notify law enforcement that company officials authorized millions of dollars in bribes in Mexico to speed up getting building permits and gain other favors. Wal-Mart has been working with government officials in the U.S. and Mexico on that investigation.

Wal-Mart has already slowed its expansion plans in Mexico, and last November it said it was looking into potential U.S. bribery law violations in Brazil, China and India.

Wal-Mart said that it expects expenses related to the Foreign Corrupt Practices Act ? which forbids American companies from bribing foreign officials ? to be in the range of $65 million to $70 million in the current quarter. The company cited that the figure is higher than the $40 million to $45 million costs it has incurred in past quarters. That's partly because the company is investing more in improving its compliance controls.

Wal-Mart said that it expects earnings per share to be in the range of $1.22 to $1.27 in the current quarter. Analysts had expected $1.29 per share.

Shares fell $1.36 per share, or 1.7 percent, to close at $78.50 Thursday. That's at the high end of its 52-week range of $61.25 to $79.96.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-05-16-Earns-Wal-Mart/id-9fd25887a0754d5a974d586a56ff4653

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Nicki Minaj to Exit American Idol: Report

Source: http://www.thehollywoodgossip.com/2013/05/nicki-minaj-to-exit-american-idol-report/

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Useful Suggestions For Your Online Marketing Needs - Maynas Eric

Most modern businesses utilize Internet promotion. Online marketing involves using advertising, search engine optimization and other methods that will generate interest and sales. This article contains advice for using online marketing techniques.

Long before site ranking becomes a concern for you, you need to build yourself an outstanding website. If you have a website, start out with this step. The more attractive your site appears, the less work it will be in the future.

Present content about your products such as a video or article to convince your visitors to purchase from your company. Doing so will ensure that your future customers are fully informed about your products before deciding to make a purchase. This demonstrates to a customer that you are not simply trying to make money from a sale. It shows that you want to provide your customers with plenty of information about your products so that they can make their own purchasing decisions.

TIP! Flashy websites look neat, but avoid making your website too distracting. When someone comes to your website you have about five seconds to capture their attention and make them want to stay.

The name internet promotion makes it seem that this type of marketing is done only on the internet; however, this is not true. Invite bloggers to conferences so you can meet them in person. You can improve a community feeling this way, making bloggers want to write all about your product or service.

Attaching your keyword to internal links is very useful. By giving visitors other links to previous posts, you can drive more traffic to your website. Internal linking helps people stay on your page for longer periods of time and can provide you with greater chances of ranking higher during search engine results.

You can make a great impression by including a banner showing your business name, mission statement or slogan. Banners are generally displayed along the top of a website or just under the title. This helps to keep your site professional while showing what you are all about. This can also help highlight any services you offer.

TIP! Internet marketing can be problematic, but you can fix it. If you know how to start your business you will be better off.

You should let your customers rate your products and leave comments of why they gave a particular rating. Honest feedback will help you offer better items for your customers, because they will be confident in buying your products since they already know that other people have tried them already.

Now here?s some advice on online marketing. Let your customers know not to worry about anything when they?re on your site. Put a site-wide link to your privacy policy at the top right corner of your site. These guarantees are a great way to gain the confidence of consumers that are iffy about shopping online. They will be more likely to purchase what you?re selling if they know you are protecting their identity.

Web marketing can be successful with dedication and hard work. You can?t find a large company who found ?luck? and ended up being powerful and successful. Was it just a coincidence that Coca Cola found success? Definitely not. Of course, none of that was possible without an aggressive and intensive marketing campaign.

TIP! To trick people into clicking on ads, create a discreet image that links to a page describing the product you are selling. Ensure you use the font that you use in your articles and linking it.

Offer proof that any claims you make about a product you are selling are true. For example, if you?re selling a Spanish course, show a video of yourself speaking Spanish to prove how well it worked for you. Make a video of yourself demonstrating your products or performing the services you advertise to convince your audience.

Do not use spam. Web crawlers, which quickly post hundreds or thousands of comments in a short amount of time, rarely produce the desired effect for your business. And actually your impersonal touch will probably turn people off and make them feel irritated instead of interested.

Having your business listed in Google is the path to success. Google is used by millions of people every day, so your company needs to be listed if you want to know exactly who is searching for you. Being listed on Google will ensure that your company is successful.

TIP! Even if you hit a few bumps in the road when it comes to internet marketing, you must persevere. You gain absolutely nothing from giving up.

Starting a blog is a great way to increase traffic. It?s crucial to have up-to-date content on your site at all times. Visitors who want and expect to follow frequent updates will stop by your site over and over again.

How good is your service or product? Having a great marketing strategy will not provide long term success for something that is of low quailty. In order to see your sales grow, you should be sure that you are marketing a quality product, one that is superior to your competitors products.

In conclusion, many businesses use Online marketing to sell products and services. Internet marketing uses methods such as search engine optimization and advertising to generate sales interest. If you remember the advice in this article, you can use Internet promotion to seriously boost interest in your own products and services.

TIP! Many businesses have a place on their website called a ?squeeze page.? It is a way to prompt your visitors to give you their email address.

Join me on Facebook:
www.facebook.com/maynaseric

Source: http://www.maynaseric.com/useful-suggestions-for-your-online-marketing-needs-4

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Wednesday, May 15, 2013

Tunnel collapse kills 2 workers at Indonesian mine

TIMIKA, Indonesia (AP) -- Rescuers have found two bodies and have evacuated three of more than 30 miners who have been trapped for a day after a tunnel caved in at a giant U.S.-owned gold and copper mine in eastern Indonesia, authorities said Wednesday.

The search was continuing for the other trapped miners, whose fate was unclear, Papua police spokesman Lt. Col. Gede Sumerta Jaya said. The cave-in occurred Tuesday at Grasberg mine in remote Mimika district in Papua, the easternmost province in the vast archipelago nation.

The mine is owned by Phoenix, Arizona-based Freeport-McMoRan Copper & Gold Inc. A statement from PT Freeport Indonesia, a subsidiary that runs the mine, said a tunnel in the underground training area collapsed. The company believed 40 employees and contract workers were in a classroom in the tunnel when the accident happened, and three workers managed to escape unhurt from the scene.

"The rescue process is difficult and will take some time to complete," the statement said. "Our thoughts and prayers are with our fellow employees and their families as we proceed with rescue efforts."

Thousands of workers are employed at the mine, which has been plagued by violence since production began in the 1970s. In 2011, production was crippled when 8,000 unionized employees walked off the job after demanding higher pay. The four-month strike ended after the company agreed to a 37 percent wage hike and improved benefits.

The restive province holds some of the world's largest gold and copper reserves.

Source: http://news.yahoo.com/tunnel-collapse-kills-2-workers-004615183.html

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Defense Department civilians furlough 11 days, not 14

May 13 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $5,849,600 2. Brandt Snedeker $3,388,064 3. Kevin Streelman $2,572,989 4. Billy Horschel $2,567,891 5. Matt Kuchar $2,493,387 6. Phil Mickelson $2,220,280 7. Adam Scott (Australia) $2,207,683 8. D.A. Points $2,019,702 9. Steve Stricker $1,977,140 10. Graeme McDowell $1,910,654 11. Jason Day $1,802,797 12. Webb Simpson $1,759,015 13. Dustin Johnson $1,748,907 14. Hunter Mahan $1,682,939 15. Charles Howell III $1,561,988 16. Russell Henley $1,546,638 17. Martin Laird $1,531,950 18. ...

Source: http://news.yahoo.com/pentagon-civilians-unpaid-leave-11-days-135934056.html

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Nancy Pelosi: If John Boehner Were A Woman, People Would Call Him 'The Weakest Speaker In History'

WASHINGTON -- Not only is House Speaker John Boehner (R-Ohio) a weak leader, but if he were a woman, people would be calling him "the weakest speaker in history," House Minority Leader Nancy Pelosi (D-Calif.) said Monday.

During an interview on MSNBC's "All In With Chris Hayes," Pelosi, who served as House speaker for four years before Boehner took over, was asked point-blank if she thinks Boehner is a weak speaker.

"I will say this about John Boehner, and I have a good relationship" with him, Pelosi said. "If he were a woman, they'd be calling him the weakest speaker in history."

She said Boehner deserves that title because House Republican leaders "have never been able to pass anything without our coming to the rescue." The one exception to that rule, she said, is the GOP's "nasty" and "unprincipled" budgets.

"You know what, if a woman was speaker and nothing was happening in this way, they'd say, 'Oh, my gosh. Oh, my gosh,'" Pelosi said. "I'm just getting a little, shall we say, tired of some of the ways they take a pass on some and not on others. We get criticized for accomplishing things. They don't get criticized for not accomplishing things."

A request for comment from Boehner's office was not immediately returned.

It's true that Boehner has relied on Democrats to pass nearly all major bills out of the House this year. There are nine enacted bills and joint resolutions so far in this session of Congress. Of those, Boehner violated the so-called Hastert Rule -- an informal requirement that a majority of the majority supports a bill in order to bring it to a vote -- four times to get them passed. Those bills include the fiscal cliff deal, Hurricane Sandy aid, the Violence Against Women Act reauthorization bill and a bill relating to federal acquisition of historic sites.

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Source: http://www.huffingtonpost.com/2013/05/13/nancy-pelosi-john-boehner_n_3269336.html

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The Tiny Seahorse's Tail Could Help Create A New Type of Armor

Seahorses are amazing little creatures?the males give birth, they swim upright and they're incredibly adorable. But did you know that the seahorse is one of the toughest little creatures on our tiny little world? In recent tests, researchers have found that the tail of the underwater equine can be compressed to about half its size. And that could have major implications for how we build the armor of the future.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/N6zZoCrjixE/the-tiny-seahorses-tail-could-help-create-a-new-type-o-504493149

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Tuesday, May 14, 2013

New drug reverses memory deficits and slows Alzheimer's in mice

May 13, 2013 ? A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings, published May 14 in the journal Alzheimer's Research and Therapy, may pave the way to a new treatment for Alzheimer's disease in humans.

"J147 is an exciting new compound because it really has strong potential to be an Alzheimer's disease therapeutic by slowing disease progression and reversing memory deficits following short-term treatment," says lead study author Marguerite Prior, a research associate in Salk's Cellular Neurobiology Laboratory.

Despite years of research, there are no disease-modifying drugs for Alzheimer's. Current FDA-approved medications, including Aricept, Razadyne and Exelon, offer only fleeting short-term benefits for Alzheimer's patients, but they do nothing to slow the steady, irreversible decline of brain function that erases a person's memory and ability to think clearly.

According to the Alzheimer's Association, more than 5 million Americans are living with Alzheimer's disease, the sixth leading cause of death in the country and the only one among the top 10 that cannot be prevented, cured or even slowed.

J147 was developed at Salk in the laboratory of David Schubert, a professor in the Cellular Neurobiology Laboratory. He and his colleagues bucked the trend within the pharmaceutical industry, which has focused on the biological pathways involved in the formation of amyloid plaques, the dense deposits of protein that characterize the disease. Instead, the Salk team used living neurons grown in laboratory dishes to test whether their new synthetic compounds, which are based upon natural products derived from plants, were effective at protecting brain cells against several pathologies associated with brain aging. From the test results of each chemical iteration of the lead compound, they were able to alter their chemical structures to make them much more potent. Although J147 appears to be safe in mice, the next step will require clinical trials to determine whether the compound will prove safe and effective in humans.

"Alzheimer's disease research has traditionally focused on a single target, the amyloid pathway," says Schubert, "but unfortunately drugs that have been developed through this pathway have not been successful in clinical trials. Our approach is based on the pathologies associated with old age-the greatest risk factor for Alzheimer's and other neurodegenerative diseases-rather than only the specificities of the disease."

To test the efficacy of J147 in a much more rigorous preclinical Alzheimer's model, the Salk team treated mice using a therapeutic strategy that they say more accurately reflects the human symptomatic stage of Alzheimer's. Administered in the food of 20-month-old genetically engineered mice, at a stage when Alzheimer's pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.

In a different experiment, the scientists tested J147 directly against Aricept, the most widely prescribed Alzheimer's drug, and found that it performed as well or better in several memory tests.

"In addition to yielding an exceptionally promising therapeutic, both the strategy of using mice with existing disease and the drug discovery process based upon aging are what make the study interesting and exciting," says Schubert, "because it more closely resembles what happens in humans, who have advanced pathology when diagnosis occurs and treatment begins." Most studies test drugs before pathology is present, which is preventive rather than therapeutic and may be the reason drugs don't transfer from animal studies to humans.

Prior and her colleagues say that several cellular processes known to be associated with Alzheimer's pathology are affected by J147, including an increase in a protein called brain-derived neurotrophic factor (BDNF), which protects neurons from toxic insults, helps new neurons grow and connect with other brain cells, and is involved in memory formation. Postmortem studies show lower than normal levels of BDNF in the brains of people with Alzheimer's.

Because of its broad ability to protect nerve cells, the researchers believe that J147 may also be effective for treating other neurological disorders, such as Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis (ALS), as well as stroke, although their study did not directly explore the drug's efficacy as a therapy for those diseases.

The Salk researchers say that J147, with its memory enhancing and neuroprotective properties, along with its safety and availability as an oral medication, would make an "ideal candidate" for Alzheimer's disease clinical trials. They are currently seeking funding for such a trial.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/k0o8ZSyH9cg/130513202449.htm

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