'Power of it was dizzying': first-person accounts

Overnight winds from Sandy blew over this tree in New York. Click image to see more Sandy photos. (Stephanie Jeannot/Yahoo! Contributor Network)

From Florida to New England, residents along the eastern seaboard are sharing their anecdotes, photos and videos of Hurricane-turned-"Superstorm" Sandy. Below are excerpts from the latest dispatches from people living through the storm. All times on posts are ET. Interested in writing about your experiences? Share your story at Yahoo! Contributor Network and your Sandy photos on Flickr.

TUESDAY

5:38 p.m.

'Never seen anything like it'

EAST MEADOW, N.Y.?Heavy winds from Hurricane Sandy resulted in several trees getting knocked down here on Long Island.

East Meadow, located in the heart of Nassau County, was ravaged by strong rainfall, severe winds and storm-like conditions on Tuesday.

At my home in Nassau County, my family and I experienced a major scare when howling winds knocked several branches down late on Monday evening.

On Tuesday, many folks on my block were without power, and left to clean up fallen leaves and branches left in the aftermath of the hurricane.

I have never seen anything like it in my 30 years of living in the New York-metro area.

? Eric Holden

3:52 p.m.

Discovering my tree-impaled car in Queens

QUEENS?As I walked out of my apartment building today, the streets were covered in debris from last nights storm. I turned the corner to find a huge branch impaling the passenger side of my windshield.

I quickly unlocked the vehicle to check if there was any internal damage. Although there was glass all over the interior, there seemed to be no major damage to it. The branch that fell was about 10 to 15 feet long and allowed some water to flow into the car. Luckily, there seemed to be no major mechanical issues with the vehicle.

After calling my insurance company, I'm now out $1,000 for the cost of the deductible. Due to the high claim activity, I will be forced to wait at least a week for my car to be processed and fixed.

? Mike Wong

2:36 p.m.

Sandy 'by far the worst' storm in 30 years in Jersey

FREEHOLD TOWNSHIP, N.J.?I have been a resident here for the past 30 years. Hurricane Sandy is by far the worst hurricane to hit my town. Strong winds and rain began on Monday in the afternoon. We lost power at 4:36 p.m. The height of the storm came around 8 p.m.

This morning, I drove around the neighborhood to survey the damage. There were fallen trees and power lines everywhere.

We are still without power. All of my neighbors and friends are without power. These images show the damage done by Hurricane Sandy. And this is within just a few blocks.

? Edwin Torres

Sandy tore trees from the ground and downed power lines in this New Jersey neighborhood. Click image to see more Sandy photos. (Edwin Torres/Yahoo! Contributor Network)

2:19 p.m.

Weathering 'Superstorm' Sandy in Jersey

DELRAN, N.J.?Many of our neighbors lost power, but we lucked out. We went outside Tuesday and noticed a lot of small and large branches scattered about our front and backyard. A neighbor, just down the street, however, was not so lucky. A very large tree took out the entire side of their house and crushed a car in the driveway. Luckily, the family living in the house was safely rescued and there were no injuries.

Now all we can do is wait, listen to the news and help out wherever we can. We have been told there could be more rain today, so there is still danger of trees falling and flooding not receding.

? Julie Wimmer

11:46 a.m.

Park Slope retains power, mostly intact

BROOKLYN?On the morning after Hurricane Sandy made landfall, millions of New Yorkers were still left without power. However, in the area surrounding Prospect Park, this is not the case. Residents, including myself, still have power, and but for a few flickers here and there during the heaviest winds, never lost it. At the same time, the comparative lack of winds and higher elevation as opposed to other parts of Brooklyn have also left Park Slope free from flooding.

Other than a few gusts of wind here and there, the weather in Park Slope is nothing that would prevent myself or any other residents from going about their daily business. With that said, because of the major flooding elsewhere in the city, and especially in a number of subway tunnels, Brooklynites are basically stranded until further notice. A small price to pay for escaping the brunt of the storm mostly intact.

? Zev Ketura

Scenes from New York City on Monday. (Photos by Scott Witt/Flickr)

10:38 a.m.

Sandy creeps into northern Ohio, bending trees and whipping winds

MARBLEHEAD, Ohio?This morning, obsessed with going out into what felt like 60 mph winds, I donned a raincoat and rubber boots and went. Making my way around the side of the house situated next to a tall boat barn, I was almost pushed over despite the wind cover. I stiffened my legs against the force, but knew staying out any longer, I'd be down. The power of it was dizzying. Not very sure about whether a tree on our partly wooded lot might timber down on me in the darkness, I was back inside in a flash.

Trees are bent over ready to touch the ground. Overnight, the autumn colors disappeared. Skies outline barren rain-soaked tree branches. With snow season upcoming, normally we would have had an artistic study in black and white. Yet now, the horizon is an imperious miserable grey. A storm like Sandy serves us as a memento of how utterly small we really are in this universe.

? Caralell Gibson

12:30 a.m.

In New Jersey, trees falling and wind howling from Sandy

DENVILLE, N.J.?The tree fell easily. It was a thud. The lights flickered and came back on. It's a shock to think we still have power at this point but we are one of the lucky ones. I'd expect that will change soon.

When the winds blow, it sounds like a freight train. As I write, I read posts from my friends across New Jersey. Trees are down everywhere. Nearly everyone is without power. Each time I hear a strong gust the lights flicker and I hear something else hit the house.

My family and I have a makeshift camp in our basement where we will all sleep this evening. The chance of a tree falling on the house makes it too unsafe to be anywhere else. Only a few blocks away, this tree (pictured above) overturned and gratefully did so across a lawn. It missed the home and cars... more importantly it missed people.

We are now in the heart of the storm as the gusts are expected to keep up until midnight tonight. I fear for what we will see when daylight comes tomorrow

? Gioia Degenaars

12:18 a.m.

New York streets dangerous with falling debris

BROOKLYN?As the night progresses, it is getting scarier. The wind is coming in through every crevice of the old buildings many of us live in. Massive power outages are beginning to affect the city. Internet is starting to crash as well.

The FDR (a major highway in NYC) is flooded. This is a big outlet to and from the city. Crashes and clangs are being heard from outside. Making many of us wonder what is flying through the streets. Stores are closed. ATMs are malfunctioning.

While stepping out to throw out a smelly bag of trash, a piece of metal scaffolding flew down from more than five stories up and landed within four feet of me. (See picture.)

Winds are more dangerous than they feel right now. This city has much debris, making it seriously dangerous outside.

? Melissa Walker

12:02 a.m.

Sandy uproots tree, smashes Queens garage

QUEENS?Earlier Monday, a huge tree in Queens was knocked over by the powerful winds of Hurricane Sandy. Luckily no people were hurt; the tree just crushed the garage. As I walked by, I snapped pictures of the accident and you can see how it just barely missed the main house on the left.

The Forest Hills Gardens neighborhood in Queens is known for its English-style homes and large trees. However, during storms like this, it's best for the residents to stay indoors, take in their Halloween decorations, and park their cars in the garage. The force of the hurricane winds are so fierce you have to worry about the whole tree and not just the falling branches.

? Mike Wong

A tree smashed into this garage in Queens on Monday. Click image to see more Sandy photos. (Mike Wong/Yahoo! Contributor Network)

MONDAY

11:49 p.m.

Lulled for 'Superstorm' Sandy by indolent Irene

HOBOKEN, N.J.?As I sit in my darkened apartment, typing with a flashlight, I cannot believe that Sandy seemed inconsequential only 12 hours ago. 48 hours ago, I was enjoying the beginning of a weeklong series of Halloween celebrations for my three young children. Now, I sit with sewage-laden flood waters lapping at my children's bicycles and beloved possessions in the garage while the water inexorably rises through the building stairwell, leaving destruction in its wake.

Hoboken has hurricane fatigue. With two major storms in 14 months and the letdown of evacuating homes that remain pristine during our absences, my neighbors blithely disregarded the storm warnings over the last few days; virtually no one evacuated.

I first became aware that the threat was serious when I woke up on Monday morning to a picture of flooding at the Hoboken train station. Reports came in through the morning of high levels of water first lapping at the Hoboken waterfront and then flooding Sinatra Drive. The highest point in Hoboken, Castle Point, never floods -- until today. Heavy wind took down trees around City Hall and led to the explosion of a power station that plunged half of Hoboken into darkness. In anticipation of losing power, I established a text message group to stay in contact with local parents. The reports trickling in became increasingly dire as the storm surge moved west. Car alarms and explosions have punctuated the night.

? Kathy Zucker

6:40 p.m.

In Virginia, empty shelves at stores

FAIRFAX COUNTY, Va.?At noon, I took it upon myself to visit a couple of my friends and go around the city of Herndon to randomly ask how people are dealing with the preparations for the storm.

We went to the shopping mall and asked a woman, Janice, what she thinks. She said she's glad for the storm because it finally gives her a break from all the boring election news coverage on TV.

Brad Dansky, 22, said he "scored bananas and an LED flashlight at the 7-11. Woohoo."

Janette, 51, said she's taking bets with all her friends on how many leaks she'll find in the ceilings of her house this week and that she's going to brunch like there's no tomorrow.

Wendy Shaw, 34, says her plan of attack for the hurricane is to "get a few party boxes of tacos and call it a day."

We were surprised that there were a group of guys playing flag football in their yards. They said, "Sandy? BRING IT ON!!"

? Samuel Gonzales

6:24 p.m.

Hurricane Sandy flexes her power on Long Island

LONG ISLAND?Just past noon, I went out to take a few pictures expecting to do a before and after. Sandy had other plans, though. The water had already come inland in several places blocking roads and causing evacuations. Trees and telephone poles were down before 2 p.m.. Here are a few of the pictures I took today. The storm still hasn't really hit us here yet. I shudder to think the kind of damage we are about to experience.

? Edward J. Neary

Hurricane Sandy's storm surges flood portions of Moriches Inlet on Long Island on Monday afternoon. (Edward J. Neary/Yahoo! Contributor Network)

4:10 p.m.

Power still on in Far Rockaway in Queens

QUEENS?Folks around town crowded the local grocery store, Food Dynasty, and purchased huge amounts of food. I was one of them. While some people left Far Rockaway, others in the houses near me and the apartment building I live in stayed. For a while, things seemed calmed. The wind picked up, then died down.

By late this morning, the wind hit the building pretty hard and I could hear the wind's blasts. While there has been rain, my apartment in Far Rockaway has not experienced flooding as of 2:10 p.m.

At times, though, the whole building seems to shake. Power has not been affected. One lone man left the building during the storm. I wasn't sure who he was or why he was leaving the building in the middle of the storm on his bicycle. I just sat in my room, waiting for the storm to blow over, thankful I still had power.

? Justin Samuels

4:03 p.m.

Wind gusts increasing in Morris County, New Jersey

DENVILLE, N.J.?Hurricane Sandy is a monster to be sure. My family and I have tied down everything we can outside. We have a make-shift camp in our basement for fear of downed tree limbs. We are as ready as we can be for power outages. We sit and wait for Sandy's approaching wrath.

Gusts have already started that will reach upward of 60 to 70 mph by this evening. The trees swaying in the back are a fearful reminder of the damage that this storm can bring to us in northern New Jersey. While we do not have the ocean to contend with, we do have many rivers and large trees that can damage our homes.

? Gioia Degenaars

3:59 p.m.

Sandy already bringing down tree limbs in New York

BROOKLYN?As the storm approaches New York City, residents are preparing to hunker down for the immediate future. As of 2 p.m. on Monday in Crown Heights (in central Brooklyn) the storm gusts are increasing and the streets are pretty much empty.

Trees are starting to go down and branches litter the street. The winds are not very high, but as they increase, the damage will be much greater. With expected gusts up to 75 mph and with trees already going down with gusts of around 35 mph, this has the potential to be damaging as the buildings start creating a wind-tunnel effect.

Transportation has ground to a halt and the schools are closed. As a transplant from the South, weathering a storm of this magnitude in the Northeast is a bit odd. As the flooding in areas in NYC increases, watching the news turns those of us not in the evacuation zones into outsiders looking in, as well.

? Melissa Walker

A view of a flooded street in New York on Monday. Click image to see more photos. (Photo courtesy of Nick Cope via Melissa Walker/Yahoo! Contributor Network)

3:42 p.m.

A stormy wedding, thanks to Hurricane Sandy

QUEENS?My wedding is in four days. And while most of the preparations are ready, there are a few things that went wrong and need to be handled last-minute.

Last night, I was visiting my fiance's relatives in Massapequa. An hour after we got back to my mom's house in Elmont, we found out that they had to evacuate their home. His cousins in Long Beach were supposed to evacuate as well since they live right by the water, but they decided to stay home. They've since put up pictures on Facebook of the deluge outside their front steps as well as a snapshot of a reporter from ABC News coming over to interview them.

When I first heard about the magnitude of the storm, one of my first thoughts was, Oh no, I never got wedding insurance. And I sure as heck won't be able to get it now. When I was on the fence about purchasing wedding insurance, I thought that it ultimately wouldn't come in handy because the only disaster I could think of was a snowstorm, and those don't happen in this part of New York in November.

? Tricia Bangit

2:46 p.m.

On Upper East Side, Sandy is bad, but not horrible yet

MANHATTAN?Power remains on, the streets still have people and cars and, except for the pending arrival of the really bad weather, it seems like any other day.

Reports from friends and co-workers from the Jersey shore to Long Island say that the ocean is really kicking up and flooding has been anywhere from moderate to very bad. A friend reports that water was coming up to Ocean Avenue in Belmar, N.J., and another friend who decided to stay in her apartment in Battery Park is reporting water on the rise.

Do not be fooled, the worst is yet to come! Rain, wind and flooding will all increasingly worse as the day progresses. Stay inside or head to a shelter.

? TR Threston

1:27 p.m.

Blustering hollers of wind in New York

QUEENS?Earlier, I tweeted, "Hurricanes are always such teases. It's 2012. Bring on a real apocalypse already." Perhaps that was a bit arrogant, and I'll fully understand the irony should this hurricane murder me. However, I'm confident that it will sweep over with little impact on my life.

Outside, its effects are definitely being felt. The closure of the MTA for any given amount of time surely impacts business and industry substantially. I'm curious what operations may still be up and running during this windy mess. I've occasionally looked outside to see the trees moving back and forth from the gusts. The streets are mostly empty. I've seen no people today, but did see a single car driving around earlier.

I'm doing what I should do to stay safe: absolutely nothing. The real danger, if there is any, would be outside. So, I'm staying inside, and you should probably do the same. There are mandatory evacuations apparently happening in the major flood zones. I happen to be in a groove surrounded by Zone C, the least likely to flood. So, even if Zone A is in danger, my apartment building should be fine.

? Clayburn Griffin

11:22 a.m.

Expecting Hurricane Sandy floods in Denville and Rockaway, N.J.

DENVILLE, N.J.?This year we are ready. We've sand-bagged. We've moved things out of the way of water. We've lowered lakes and boarded up. Yet, something about Hurricane Sandy fills us with a dread that most of us in New Jersey cannot shake.This picture is a scene from the Broadway area of Denville on Sunday afternoon.

Residents of Denville and Rockaway are expecting the Rockaway River to spill over its banks and cause massive flooding just one year after Hurricane Irene nearly wiped out the main street.

? Gioia Degenaars

11:01 a.m.

Hurricane Sandy takes aim at northeastern Pennsylvania

MILFORD, Pa.?As of 10 a.m. on Monday morning, the track of Hurricane Sandy puts it just a few short hours away from here in northeastern Pennsylvania.

But already the winds are picking up in Pike County.

It is anticipated to make landfall along the Delaware coast, just south of Philadelphia. By the time the eye reaches inland, the winds are expected to cause it to be downgraded to a tropical storm. But by then, the damage for areas such as Pike County will have been done. Traditionally in this area, the rain will loosen the ground beneath trees and power poles. The high winds then rip these from the ground. In the past power has been off for days and weeks at a time. With the predictions calling for this storm to be worse than Irene of just two years ago, residents are gearing up for the worst: They're buying up water and staple foods at our local Wal-Mart, Kmart and other grocery stores. Even convenience stores like the Turkey Hill in Milford are feeling the panic.

? Charles B Reynolds

Source: http://news.yahoo.com/blogs/lookout/hurricane-sandy-wet-loud-monster-residents-stories-storm-203210634.html

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Askewl dot com ? Real estate investment gurus along with legal ...

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Source: http://askewl.com/real-estate-investment-gurus-along-with-legal-professionals/

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VitaMedica Video Series Makes Recovery after Plastic Surgery Easy

Manhattan Beach, CA ( freepressreleases ) October 11, 2012 ? VitaMedica developed a series of Recovery Products tutorial videos to help patients determine the best recovery nutritional solution for their upcoming plastic surgery procedure. In the videos, Dr. David H. Rahm, medical director and founder of VitaMedica, discusses the importance of nutrition for recovery. He also reviews the use of Arnica for bruising, bromelain for inflammation and vitamins for immune support and wound healing.

In an increasingly competitive employment market, many women and men are resorting to cosmetic surgery to look their best. But with limited vacation days and a high interest in discretion, it?s no surprise that patients want to minimize recovery and downtime.

With internet search rates for plastic surgery preparation and recovery closing in on 90 million per month, it?s clear that patients want to take a proactive approach to improving their recovery time.

So, what are they seeking and finding from all these internet searches?

The most popular searches involve the use of natural homeopathic remedies like Arnica montana for bruising. Other popular searches include the use of bromelain for swelling and nutrients like vitamin C for healing. But, with so much information available on the web, identifying which products work best is a challenge for even the savviest patients.

To address this need, VitaMedica developed four new videos to help patients determine the VitaMedica Recovery product that is best suited for their upcoming plastic surgical or non-surgical procedure. These include Why Recovery Nutraceuticals, Arnica Montana & Bruising, Bromelain & Inflammation and Vitamins & Immune Support. All of the videos can be found in the Learn section of the company website.

In the Recovery introductory video, Dr. Rahm provides patients with basic guidelines for taking nutritional supplements around the time of surgery.

Dr. Rahm, who is a board-certified anesthesiologist says, ?Patients often don?t realize that a number of popular supplements can negatively affect a surgical procedure, or even cause their surgery to be canceled.?

He continues, ?While some supplements may be great for your health long-term they can actually worsen bruising and bleeding or interfere with pharmaceuticals during surgery.? This video helps bring awareness to this issue for patients.

?Providing videos on our website is just an extension of an educational focus that we?ve always had,? says Yvette La-Garde, VitaMedica?s director of education. She continues, ?We already offer a wealth of information on our website including a Recovery Products Quiz which helps patients select the best product for them but video format just makes easier for those who want to learn the information as quickly as possible.?

While not a household name, VitaMedica has offered a line of nutritionally based Recovery Products through plastic surgeons, facial plastics, cosmetic derms and medical spas for over a decade. Many of these practices not only offer a VitaMedica Recovery product as part of the overall price of a procedure but also provide guidance on the best nutraceutical to accompany a patient?s procedure.

But, more recently, the company started offering its Recovery product line directly to patients via their website. This approach is ideal for patients who have heard about the benefits of using VitaMedica but whose doctor does not carry the product line ? typically a non-aesthetic practice. The downside is that these patients need more education about which VitaMedica Recovery product is best suited for their needs.

For a full list of supplements to discontinue around the time of surgery, refer to VitaMedica?s Surgery Supplements Guidelines. For more information on the dietary & lifestyle measures you can take to support healing and speed recovery, see VitaMedica?s Recovery Guidelines.

Since 1997, VitaMedica has offered a targeted line of nutraceuticals for recovery and wellness through aesthetic medical practices including plastic surgeons, facial plastic surgeons, cosmetic dermatologists, medical skin care clinics and medical spas. For more information, please call VitaMedica at 1-888-367-8605 or visit www.vitamedica.com.

Contacts:

Yvette La-Garde
Director of Education
Phone: 888-367-8605 ext 102
Email: moc.acidemativnull@ettevY

###

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Source: http://www.freepressreleases.com/vitamedica-video-series-recovery-plastic-surgery-easy/263132

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I lost 100lbs in 6 months , My Body Transformation Photos ...

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Wall Street posts worst week since June, banks weigh

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Traders work on the floor of the New York Stock Exchange at the opening of the trading session in New York October 5, 2012. 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Video game Arian Foster Jersey Much Better Than Your Competition ...

From your about three year old understanding Arian Foster Jersey the alphabet, to your soldier finding out how to protect his guidelines on the front side outlines, games genuinely have one thing for people all. You can find games to minimize your stomach-range, increase your IQ or just require clear of everything for some time. Read on to understand more about this fascinating world.

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Source: http://www.hugohosting.com/video-game-arian-foster-jersey-much-better-than-your-competition-by-using-these-ideas.html

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This 14-Year-Old Kid Is a Lego Genius [Lego]

This is Stijn Oom, a 14-year-old kid from the Netherlands. Stijn started to play with Lego right after he was potty trained (literally). More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/WY8ZiuLr-OM/this-14+year+old-kid-is-a-lego-genius

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Dell Goes for the Windows 8 Gold

With Microsoft's next-generation Windows 8 operating system set to launch later this month, Dell on Friday announced new computers that will support it: the Dell XPS 12 convertible laptop, the Dell XPS One 27 all-in-one desktop, and the Dell Inspiron One 23 all-in-one.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/246c3d95/l/0L0Stechnewsworld0N0Crsstory0C763760Bhtml/story01.htm

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Kenya's cell phone users clock 29.7mn

Today, we find that many of the western countries have advanced telecom industries. Communication plays a very vital part in the success of the economy of the country. Since these countries had access to modern technology through the support of their government for such innovations, they have made rapid strides.That is the basic reason why we find that a significant part of the population in these countries are mobile phone users. Africa on the other hand, has seen a lot of setbacks due to a variety of factors, and hence its slow pace to keep up with new technologies.

Many people in different parts of the world think of Africa as an impoverished place, that is ravaged by war and disease, but it is quite the contrary. On the aspect of technological advancement, the last decade has seen a sharp increase in technology on the continent. The number of mobile phone users has gone up substantially and Africa is now the second largest market in the world with over 600 million subscribers.

It is seen that Kenya has always been in the forefront of development. With a population of around 42mn, and a GDP Purchasing Power Parity of around US$66.03 Billion (As of 2011), Kenya remains a strong economic powerhouse on the face of Africa. During the last quarter of 2012, CCK (Communication Commission of Kenya) has announced that the country?s total number of mobile subscribers was an incredible 29.7mn, in a country of 41mn people!

This number firmly makes Kenya as one of the countries in Africa with the highest mobile penetration rates of 75.4 percent, signifying a growth of 17.5 percent from 25.2 million recorded in the 2010/2011 period. The Kenyan market has accepted the mobile phone as a primary form of communication. This access to mobile phones has even surpassed access to banks which were present here long before the mobile phones. The country heavily relies on mobile phones for both personal and commercial use. Most of the people use their mobile phones for money transaction innovations like M-pesa that has been built by the GSM networks in the country.

The rise in the number of mobiles could also be attributed to an increase in the middle class population and also government policies that are giving rise to a healthy and competitive telecommunication industry. Some of the recent policies include connecting Kenya to the rest of the world using fiber optic cables. The under sea fiber optic cable has contributed to the increase of mobile phone penetration because the GSM networks use this as a medium to provide Internet services, through SIM cards. A majority of the Kenyan population access Internet through mobile phone devices.

Source: http://www.kuzabiashara.co.ke/kenya%E2%80%99s-cell-phone-users-clock-29.7mn-21144/

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Engineered flies spill secret of seizures

ScienceDaily (Oct. 11, 2012) ? Scientists have observed the neurological mechanism behind temperature-dependent -- febrile -- seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. In addition to contributing the insight on epilepsy, their new study also highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.

In a newly reported set of experiments that show the value of a particularly precise but difficult genetic engineering technique, researchers at Brown University and the University of California-Irvine have created a Drosophila fruit fly model of epilepsy to discern the mechanism by which temperature-dependent seizures happen.

The researchers used a technique called homologous recombination -- a more precise and sophisticated technique than transgenic gene engineering -- to give flies a disease-causing mutation that is a direct analogue of the mutation that leads to febrile epileptic seizures in humans. They observed the temperature-dependent seizures in whole flies and also observed the process in their brains. What they discovered is that the mutation leads to a breakdown in the ability of certain cells that normally inhibit brain overactivity to properly regulate their electrochemical behavior.

In addition to providing insight into the neurology of febrile seizures, said Robert Reenan, professor of biology at Brown and a co-corresponding author of the paper in the Journal of Neuroscience, the study establishes

"This is the first time anyone has introduced a human disease-causing mutation overtly into the same gene that flies possess," Reenan said.

Engineering seizures

Homologous recombination (HR) starts with the transgenic technique of harnessing a transposable element (jumping gene) to insert a specially mutated gene just anywhere into the fly's DNA, but then goes beyond that to ultimately place the mutated gene into exactly the same position as the natural gene on the X chromosome. HR does this by outfitting the gene to be handled by the cell's own DNA repair mechanisms, essentially tricking the cell into putting the mutant copy into exactly the right place. Reenan's success with the technique allowed him to win a special grant from the National Institutes of Health last year.

The new paper is a result of that grant and Reenan's collaboration with neurobiologist Diane O'Dowd at UC-Irvine. Reenan and undergraduate Jeff Gilligan used HR to insert a mutated version of the para gene in fruit flies that is a direct parallel of the mutation in the human gene SCN1A that causes febrile seizures in people.

When the researchers placed flies in tubes and bathed the tubes in 104-degree F water, the mutant fruit flies had seizures after 20 seconds in which their legs would begin twitching followed by wing flapping, abdominal curling, and an inability to remain standing. After that, they remained motionless for as long as half an hour before recovering. Unaltered flies, meanwhile, exhibited no temperature-dependent seizures.

The researchers also found that seizure susceptibility was dose-dependent. Female flies with mutant strains of both copies of the para gene (females have two copies of the X chromosome) were the most susceptible to seizures. Those in whom only one copy of the gene was a mutant were less likely than those with two to seize, but more likely than the controls.

While the researchers at Brown compared the seizure susceptibility of whole flies, O'Dowd, lead author Lei Sun, and colleagues at Irvine studied individual fly neurons implicated in seizure activity to see how they behaved as the brains were heated. What their measurements revealed in the mutant flies were flaws in how "GABAergic" neurons take in sodium through channels in the cell membrane. Under normal circumstances, the neurons inhibit brain overactivity. But the mutants' mishandling of sodium led them to fail electrically.

"When [O'Dowd's team] isolates those currents due to the sodium channel, which is what's mutated in this case, and she compares the normal animals to the disease-model animals, what happens is the mutant channels pass too much current," Reenan said. "The channels open too easily and they take more effort to close. They open too soon and they close too late. That effect is magnified at higher temperature. Then the neuron can't send any [inhibitory] signals."

Searching for therapies

With a useful genetic model of epilepsy in fruit flies, Reenan said he is optimistic that researchers can now look for potential treatments for the disease. The next step, he said, is to use the practice of "forward genetics" to look for further mutations that might counter febrile seizures.

Given thousands of flies with model of the disease, scientists can purposely subject them to different DNA-altering conditions and then look to see if any flies lose their propensity for seizures. Among those that do, the researchers can then identify the specific genetic alteration responsible and determine whether that could ever be clinically applied. For example, if it turns out that a mutation proves therapeutic because it causes a certain protein to be overexpressed, then perhaps that protein could be refined into some kind of biologic pharmaceutical.

Reenan said he'd expect to see researchers follow a similar roadmap for other diseases as well.

"Knock-in of specific disease-causing mutations into the fly genome has the potential to provide a rapid and low-cost platform for studying the cellular mechanisms of heritable human diseases," the authors wrote. "In addition, knock-in flies can be used in combination with forward genetic screens to identify suppressor and/or enhancer mutations, a strategy that is challenging in humans and rodent models but well established in Drosophila."

In addition to Reenan, Gilligan, O'Dowd and Sun, other authors are Cynthia Staber of Brown and Ryan Schutte and Vivian Nguyen of UC Irvine.

In addition to the National Institutes of Health, the Howard Hughes Medical Institue and the Ellison Medical Foundation funded the research.

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The above story is reprinted from materials provided by Brown University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. L. Sun, J. Gilligan, C. Staber, R. J. Schutte, V. Nguyen, D. K. O'Dowd, R. Reenan. A Knock-In Model of Human Epilepsy in Drosophila Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure. Journal of Neuroscience, 2012; 32 (41): 14145 DOI: 10.1523/JNEUROSCI.2932-12.2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/UMGo0WkKb3w/121011151623.htm

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Zuma under fire for costly upgrade of his home

JOHANNESBURG (AP) ? New security fences. A medical clinic. Fire-fighting services added for a helipad. That and other upgrades, all for South African President Jacob Zuma's home to the tune of more than $23 million in taxpayer money. And all for his rural private residence.

Zuma is embroiled in a controversy over the costly additions to his private home in a country where millions still lack decent homes, running water, electrical power and adequate access to health and education services.

The revelations of the renovation of Zuma's rural compound, dubbed "Zumaville" in the local press, in KwaZulu-Natal come before the ruling African National Congress' December conference where Zuma seeks to be reappointed as the party's leader, and therefore its candidate for president in the 2014 national election.

Zuma's standing has already been shaken by the recent police killings of 34 striking platinum miners in the continuing wave of ongoing wildcat strikes. He is widely seen by striking miners as aloof to their concerns that they're not paid enough for the difficult and dangerous work they perform. Firebrand politician Julius Malema, ousted this year as ANC Youth League leader, says Zuma should not be allowed another term in office.

The government has refused to disclose the precise cost of the work on Zuma's countryside home. Local reports say the upgrades cost about 200 million rand ($23 million).

Zuma said at a breakfast meeting Thursday that he does not know how much the work will cost, that it was authorized by the Ministry of Works and was motivated by security concerns. Public Works Minister Thulas Nxesi said last week that work on Zuma's residence was similar to that done on those of other South African presidents.

High security fences have been erected, roads upgraded, a medical clinic added and fire-fighting services developed for the helipad at the compound, according to the South African Press Association. Speaking to reporters Wednesday, Deputy Public Works Minister Jeremy Cronin also could not confirm the cost but said the matter would be investigated for any "inexplicable overruns on costs," according to SAPA.

Some critics say the ANC party that was once led by anti-apartheid icon Nelson Mandela is overly focused on political power with too little attention being accorded to the country's black poor.

Zuma's presidency has been "marked by political problems, most notably a radical decline in the ANC's credibility. Zuma's own actions have also stripped the office he holds of dignity," wrote Pallo Jordan, a former minister of arts and culture, in an article published in BusinessDay newspaper. "Whoever the ANC membership elects in December will have to grasp the nettle of restoring the ANC's dented credibility and dignity to the office of the president."

Shadrack Gutto, a professor of African studies at the University of South Africa, said ordinary South Africans have come to expect little good from the ANC, whose top bosses have become fabulously wealthy even as millions of South Africans are mired in poverty. As some South African miners were striking for better pay, businessman Cyril Ramaphosa, an influential member of the ANC who had once been a touted as a future leader, was bidding millions of dollars for a prize buffalo.

"Every day there is a scandal here, a scandal there," Gutto said, adding that a time will come when the party will be thrown into "the dustbin of history."

Of the costly renovations to Zuma's private residence Gutto said: "It has to be investigated. It will be a scandal when the truth comes out."

Zuma, 70, remains popular in his Zulu homeland and many say he will win another term as ANC chief. He may be challenged by Deputy President Kgalema Motlanthe. The speculation has been fueled by the release this week of an authorized Motlanthe biography, as well as a decision by ANC officials in Gauteng province, where both Johannesburg and the capital Pretoria are located, to back Motlanthe.

Source: http://news.yahoo.com/zuma-under-fire-costly-upgrade-home-180338522.html

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Special Education Law 101 - Part V - Special Education Law Blog

Our series providing an introduction to special education law continues.? Previous posts have introduced the two basic concepts underlying IDEA, free and appropriate education and least restrictive environment.? Today's post concerns eligibility and identification.

Identification & Eligibility

Issues pertaining to identification and eligibility are governed by IDEA ? 612(a)(3) and 614 (b)(4)-(6).? See, 34 C.F.R, ? 300.121- 300.125, 300.300, 300.306, 300.307 ? 300.311.??

In summary, to be eligible, a child must have one of the enumerated conditions(mental impairment, a hearing impairment (including deafness), a speech or language impairment, a visual impairment (including blindness), a serious emotional disturbance (referred to in this part as ?emotional disturbance?), an orthopedic impairment, autism, traumatic brain injury, an other health impairment, a specific learning disability, deaf-blindness, or multiple disabilities)(which adversely affects his education) and by reason thereof, he must need special education and related services.? In addition as a third requirement for eligibility, most of the disabling conditions require that the condition adversely affects the child's educational performance.

Some important circuit court decisions:

Marshall Joint Sch Dist No 2 v. CD by Brian & Traci D ???616 F.3d 632, 54 IDELR 307 (7^th Cir 8/2/10) Seventh Circuit reversed HO who found student eligible solely upon physician?s opinion that the student could benefit from adaptive PE.? The Seventh Circuit noted that a physician may not simply prescribe special education; IEPT must consider relevant factors.

Alvin Indep Sch Dist v. AD by Patricia F 503 F.3d 378, 48 IDELR 240 (5th Cir. 10/4/7)? The fifth Circuit affirmed a holding that despite a fifth grader?s ADHD, he was not eligible for? special education.? The student consistently received passing grades, he succeeded on statewide tests and he was achieving in social situations.? Accordingly, he did not by reason thereof ?need special education and related services,? and, therefore, he was not a child with a disability as defined by the IDEA

Hood v. Encinitas Union Sch Dist 47 IDELR 213 (9th Cir. 4/9/7)? The Ninth Circuit applied the Rowley standard to an eligibility issue.? Where the student consistently received above average grades despite her disability, she received educational benefit, and therefore, was not eligible for SpEd.? NOTE:? One legal scholars has questioned whether the Rowley test is too restrictive for eligibility purposes, Weber, Mark "The IDEA Eligibility Mess," http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1206202

IDEA also places a child find duty upon school districts.? A district has an affirmative duty to identify and evaluate children with disabilities.? District of Columbia Public Schs (JG) 111 LRP 25934 (SEA DC 3/18/11) The standard for child find is suspicion of a disability rather than actual knowledge. District of Columbia Public Schs (JG) 111 LRP 25934 (SEA DC 3/18/11).

Compton Unified Sch Dist v. Addison 598 F.3d 1181, 54 IDELR 71 (9th Cir. 3/22/10) By a 2-1 vote, Ninth Circuit rejected school district argument? that there is no child find duty because of language pertaining to prior written notice. The district argued that only an action or refusal is a violation. The Ninth Circuit held that a parent could file a dpc on any matter related to identification, evaluation, FAPE or placement, so, therefore, child find violations are actionable.??

Ridley Sch Dist v. MR & JR ex rel ER 680 F.3d 260, 58 IDELR 271 (3d Cir 3/19/12) Third circuit conducted a detailed review of the law concerning Child Find, and concluded that the HO erred by failing to allow the school district a reasonable time to identify the student as disabled.??

Source: http://specialeducationlawblog.blogspot.com/2012/10/special-education-law-101-part-v.html

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